Monday, June 5, 2023: Polish Medical Biotech Day

1. A4BEE Sp z oo https://a4bee.com/

A4BEE is a 4-year-old tech company supporting the pharma and biotech sectors to accelerate innovation and harness connectivity, flexibility, and modularity. We provide end-2-end services like digital advisory, software & platform development, AR/VR solutions, data acquisition, and IoT hardware. Our 130-person team of engineers, developers, biotechnologists, consultants, and security experts empower global players at every stage of their digital transformation journey while solving real-world problems.

2. ADAMED PHARMA SA https://www.adamed.com

Adamed Pharma is a pharmaceutical and biotechnology company established on the basis of Polish scientific advances and its own patents. The core business of the company is the development, production, and distribution of generic drugs. Adamed Pharma Drug Discovery Department develops innovative drugs at in three therapeutic areas: diabetology, oncology, and neuropsychiatry.

3. ARDIGEN SA www.ardigen.com

Ardigen enables AI transformation for biotech and pharmaceutical companies to unlock the full potential of data. The company delivers value at the intersection of biology and computational methods to increase the probability of success and accelerate the drug discovery process.

4. AUXILIUS PHARMA SP z oo www.auxiliuspharma.com

Auxilius Pharma is an emerging and dynamic, Value AddedMedications pharmaceuticals company. We specialize in identifying and optimizing drugs with well-established clinical history and value-added potential in the cardiovascular space. We are particularly interested in reformulation projects, which pose a significant, but achievable scientific challenge, address areas of unmet medical need, and offer attractive risk-weighted return on investment potential. We base our development activities on advanced formulation technologies to improve the utility for patients, in terms of compliance, dosage frequency, route of administration, and/or side effects.

5. CAPTOR THERAPEUTICS SA www.captortherapeutics.com

Captor Therapeutics is a biopharmaceutical company focused on the development of protein degradation drugs for cancer and autoimmune diseases, which have limited or no known treatment options. A revolutionary approach of Targeted Protein Degradation (TPD) combats the therapeutic limits of small molecules by overcoming drug resistance and uncoupling their pharmacokinetics from pharmacodynamics. Breakthrough TPD technology allows the degradation of virtually any intracellular protein including the so-called “undruggable proteome”.

6. CELON PHARMA SA www.jjpbiologics.com
JJP Biologics is an innovative biotechnology company developing novel biological therapies around

established companion diagnostics.

7. EXECMIND www.execmind.com
ExecMind is a pioneer and unique Poland-based, Life Science Executive Search consulting company

connecting life sciences companies with world-class scientists and visionary leaders.

8. EXPLORNA THERAPEUTICS Sp z oo https://explorna.com

With passion, ExploRNA Therapeutics develops ground-breaking innovations of mRNA as a therapeutic platform, applies those solutions in unique therapeutic programs, and delivers technology, therapeutic platform, and therapies to pharmaceutical partners.

9. FAMICORDTX SA www.famicordtx.com

FamiCordTx is a company established to implement cell engineering therapies. Our main goal is to implement therapy based on CAR-T (chimeric antigen receptor) technology, i.e. genetically modified T-cells used for blood neoplasm treatment.

10. FUNDACJA KLASTER LIFESCIENCE KRAKÓW www.lifescience.pl

Klaster LifeScience Krakow is the network initiative to grow the innovation ecosystem located in the center of Europe, focused on Health and Quality of Life. The network involves six groups of interest: businesses, academia, research & innovation, hospitals, business support, and local government. KLSK facilitates international collaboration and provides access to the life science marketplace in Poland and EU.

11. GENOMTEC SA www.genomtec.com

Genomtec S.A. is a medical technology company dedicated to the commercialization of a fast, mobile point-of-care genetic testing platform through research and development of its proprietary optical systems and Streamlined Nucleic Acid Amplification Technology (SNAAT®). Our aim at BIO 2023 is to promote the technology for partnerships, find potential strategic investments, and explore joint- ventures and M&A opportunities for the business.

12. GENXONE SA www.genxone.eu

We have been operating since 2016, developing and promoting the opportunities offered by the nanopore sequencing technology developed by Oxford Nanopore Technologies. We are the first in Poland certified ONT partner. Our molecular laboratory specializes in diagnostics and clinical trials.

13. GYNCENTRUM Sp z oo https://gyncentrum.pl/

Gyncentrum Clinic is one of the leading centers for infertility treatment and prenatal diagnostics in Poland. An integral part of Gyncentrum is the Gyncentrum Genetic Laboratory specializing in genetic diagnosis of infertility and miscarriages and preimplantation diagnostics of PGT, Gyncentrum Hospital, and Gyncentrum Endometriosis Treatment Center. Tens of thousands of Polish and foreign patients are treated in Gyncentrum Clinics every year.

14. INTELLISEQ SA https://intelliseq.com/

Intelliseq is a genome informatics company developing bioinformatics tools for diagnostics, therapy, and prevention based on genetic data. We offer ready-to-use workflows for PGx, Germline Disorders, Somatic Cancer, and Polygenic Risk Scoring all wrapped up in one user-friendly platform. The system drives lab efficiency through streamlined raw DNA data-to-reporting workflows.

15. INTODNA SA https://intodna.com/

intoDNA is a growing biotech start-up that offers an end-to-end process for DNA break detection with STRIDE, its proprietary technology. It is an innovative technology that outcompetes any other tools in its sensitivity, providing a reliable measure of DNA damage at an individual lesion level. STRIDE has been successfully used by leaders in the biotechnology and pharmaceutical industries and renowned academic groups in DNA damage response, cancer immunotherapy, and nuclear medicine fields.

16. JAGIELLOŃSKIE CENTRUM INNOWACJI Sp z oo www.jci.pl

The Jagiellonian Center of Innovation company was established in 2004 by the Jagiellonian University in Krakow with a view to developing and managing the infrastructure of the Life Science Park as well as providing a wide range of services to entrepreneurs and scientists engaged in life sciences. During the years 2009 – 2013, JCI primarily offered such services as laboratory space rental, project grant management as well as providing funding for businesses within the framework of the JCI Venture fund.

17. JJP BIOLOGICS Sp z oo www.jjpbiologics.com
JJP Biologics is an innovative biotechnology company developing novel biological therapies around

established companion diagnostics.

18. KAWA.SKA Sp z oo www.kawaska.pl

Distribution of systems dedicated to life science research, biotechnology, and medicine, consulting and education in this field of application.

19. KRZYSZTOF KUCHARCZYK TECHNIKI ELEKTROFORETYCZNE Sp z oo www.kucharczyk.com.pl ;www.biovectis.com

BioVectis is developing, manufacturing, and marketing Life Sciences R&D tools for in vitro protein-protein and protein-nucleic acids interaction analysis using proprietary equipment and kits for ultraprecise electrophoretic mobility shift assays. The main product of the DNAPointerTM System offers a worldwide unique level of (0,1°C ) temperature control during the native electrophoretic separation of e.g. of RNA conformers, ssDNA, and native protein complexes. Also, this platform facilitated a time and cost-effective RNA secondary structure analysis and minor genetic variants discovery and detection down to the 0,1% level at heterogeneous oncological and virological clinical material.

20. LEADERNA BIOSTRUCTURES Sp z oo www.leaderna.com

Leaderna Biostructures since 2015 supports US and EU-based Pharma/Biotech companies (including 2 of the biggest) in drug discovery. We provide services and consultancy in the field of structural biology using the most advanced technologies like cryoEM or X-ray crystallography. The Gene-to-Structure approach allows understanding the atomic details of the binding of the potential drug (e.g. small molecule, antisense DNA, RNA) to the target protein.

21. MABION SA https://www.mabion.eu/

With a history that spans 17 years, Mabion has a wealth of experience in biological development and manufacturing, making us well-positioned to deliver on clients’ needs and requirements. With extensive bioanalytical capabilities and expertise in sterile manufacturing, including packaging and serialization, we offer end-to-end CDMO services.

22. MEDICOFARMA BIOTECH SA www.medicofarmabiotech.pl

Medicofarma Biotech is a company listed on New Connect, our work efforts focus on innovative medicines, medicinal and biotechnology products. The goal of Medicofarma Biotech is to design, refine and introduce medication to the market to deliver a breakthrough in the prevention and treatment of modern-age diseases. To this end, we base our efforts on modern technological infrastructure as well as the know-how of experienced specialists. We are on the lookout for new partners in the areas of science, clinical research, and business.

23. MOLECULE ONE Sp z oo https://molecule.one

Molecule One is an AI-first biotechnology company that supports drug discovery pipelines with predictive systems for chemistry. We use our proprietary machine learning technology and high-throughput laboratory to create solutions to support small molecule discovery through more effective experiment design. We were the first company worldwide to commercialize an AI-enabled system for retrosynthesis.

24. MOLECURE SA https://molecure.com/

Molecure is a clinical-stage biotechnology company that uses its world-leading medicinal chemistry and biology capabilities to discover and develop first-in-class small molecule drug candidates that directly modulate underexplored protein targets and the function of RNA to treat multiple incurable diseases. We have generated a diverse pipeline of seven distinct programs with the support of leading academic life science institutions globally. Our most advanced in-house drug candidate is OATD-01, a first-in-class chitinase inhibitor for the treatment of interstitial lung diseases such as sarcoidosis and idiopathic pulmonary fibrosis and our second proprietary candidate is OATD-02, an oral, potent and selective first-in-class, dual arginase inhibitor (ARG1 and ARG2) for the treatment of cancer.

25. ORPHINIC SCIENTIFIC SA www.orphinic.com

We cooperate with biotech companies on preclinical and clinical research. We also invest in those companies and after a successful development process of phase 1 or phase 2 sell the project to big Pharma.

26. PIKRALIDA Sp z oo https://pikralida.eu/en/

Pikralida is a young biopharmaceutical company (est. February 2019) developing medicinal products to address unmet medical needs while providing the highest efficacy and safety in pharmacotherapy. Our currently implemented projects include therapeutic solutions based on innovative small-molecule substances, innovative formulations of combination drugs, and modern drug delivery systems. The needs of patients suffering from civilization and neurological diseases and those from the geriatric population are the primary focus of our work. Drawing on the unique expertise and experience of its scientific team, Pikralida offers professional R&D services in a CRO (Contract Research Organization) model in the scope of drug discovery and development, which include chemical synthesis, the development of formulations, and pharmaceutical analysis.

27. PIOLIGON SP z oo https://pioligon.pl/

We use a completely new approach to the discovery of therapeutical peptides and hit molecules in general. Our VPDesigner42TM platform consists of in silico method and complementary chemistry and can significantly boost your hit and lead discovery for difficult targets, including protein–protein interactions, and make the discovery process more environmentally friendly.

28. POLSERVICE KANCELARIA RZECZNIKÓW PATENTOWYCH Sp z oo www.polservice.com.pl

We provide comprehensive legal services in all matters concerning the protection and enforcement of widely defined industrial and intellectual property. Our clients include international corporations, small and medium-size domestic enterprises, individual creators, as well as public universities and research institutes.

29. POLTREG SA https://poltreg.com/

Poltreg is one of the world leaders in cellular therapies based on T-REG cells. We at the clinical stage in the treatment of Diabetes Type I (T1D) and Multiple Sclerosis. Our T1D therapy has received the ATMP status from European Medicines Agency (EMA). Based on that Poltreg already runs early access commercial TREG therapies for patients with newly diagnosed T1D.

30. PURE BIOLOGICS SA www.purebiologics.com

Pure Biologics is a biopharmaceutical company focused on biological drug and non-systemic therapies discovery and development based on our own technology platforms for the selection of active molecules – antibodies and aptamers. Pure Biologics also offers commercial partnership options in several areas including early-phase biological drug discovery and development, selection, and characterization of antibodies and aptamers, as well as protein production, purification, and analysis.

31. REAL RESEARCH Sp z oo www.real-research.com

Real Research Sp. z o.o. is a young Biotechnology Start-up creating solutions for 3D cell culture and developing other technologies related to cell culture. The company’s mission is to change the way research is conducted at LifeScience, in particular, to popularize 3D cell culture.

32. RYVU THERAPEUTICS SA https://ryvu.com/
Ryvu Therapeutics is a clinical-stage drug discovery and development company focused on novelsmall molecule therapies that address emerging targets in oncology.

33. SANO CENTRE RESEARCH INSTITUTE – CENTRUM ZINDYWIDUALIZOWANEJ MEDYCYNY OBLICZENIOWEJ – MIĘDZYNARODOWA FUNDACJA BADAWCZA www.sano.science

Sano Science is an International Research Institute dedicated to the advancement of computational medicine. We are developing sophisticated computer methods for the prevention, diagnosis, and assistance of the treatment of diseases, to meet the overarching worldwide need for efficient, effective, and streamlined healthcare. Our aim is to help clinicians to take better care of patients and to become the biggest Centre for Computational Medicine in Europe.

34. SDS OPTIC SA https://sdsoptic.pl/

SDS Optic has been founded mid 2013 as limited liability company with the focus to develop photonics technologies in healthcare space. SDS Optic Inc. is the first ever European-based cutting-edge MedTech connecting molecular biology with novel photonics technologies, chemistry & biomedical engineering to create solutions that can revolutionize healthcare worldwide, incl. the first ever In Vivo Photonics Immunoassays platform – inPROBE® technology. We discover, develop and commercialize disruptive diagnostics and monitoring tools on a global scale, creating Lifesaving Innovations to help medical professionals in the real-time diagnosis and monitoring of therapy increasing Patients’ well-being. Our vision is to help increase cancer survival by 30% by 2030 and co-create the future of fighting cancer as well as other serious chronic diseases.

35. SYVENTO SP z oo www.biotech.syvento.com

SyVento BioTech is an expert in providing technologically advanced, innovative solutions for closing active substances. The company specializes in the research and development of innovative raw materials for pharmaceutical products based on the technology of encapsulation in lipid carriers (small molecule substances, nucleic acids). SyVento also deals with consulting and optimization of the production process of liposomes and lipid nanoparticles as well as mRNA synthesis.

36. SOLUTION4LABS Sp z oo https://solution4labs.com/en/

At Solution4Labs, we prioritize progress. Our offer provides modern laboratories and research units with solutions ensuring the highest quality of operation and compliance. As a Thermo Fisher Scientific Authorised Partner, we create systems that match real needs and provide our clients with cutting-edge technology to improve processes, facilitate research, and excel at lab management.

37. WPD PHARMACEUTICALS Sp z oo www.wpdpharmaceuticals.com

WPD Pharmaceuticals focuses on developing biological and chemical molecules involved in targeted therapy for brain gliomas and other central nervous system cancers. WPD has exclusive rights (worldwide or for specific territories) for several novel drug candidates in either preclinical or clinical stage development. WPD is well prepared and organized to create and implement clinical development strategies, including interaction with the EMA and other regulatory bodies, as well as CRO and program supervision. In addition to developing in-house and co-development programs, WPD can provide these services commercially to US and EU companies.